Zhu Ling - Polyporus umbellatus

Professional Data
 Pin Yin
Zhu Ling
Sclerotium Polypori
 Introduction Back to Top
Sclerotium Polypori is the dried sclerotium of Polyporus umbellatus (Pers.) Fires (Fam. Polyporaceae). The drug is collected in spring and autumn, removed from soil, and dried.

 Western medical Back to Top
This herb is often used to treat urinary disturbance, jaundice and tumors.

 Eastern medical Back to Top
  • Pattern: Induces diuresis, eliminates Dampness.
  • Properties: Sweet, neutral.
  • Channels entered: Kidney, Bladder.
 Chemical constituents Back to Top
zhu ling contains ergoterol, biotin, polyporenic acid A and C, polyporusterone and polysaccharide, etc..

 Pharmacological actions Back to Top
Diuretic effect

8g zhu ling administrated to normal adults could increase the 6-hour urine volume and urine chloride by 62% and 54.5% respectively.

Anti-tumor effect

Polysaccharide of zhu ling had anticancer effect. Intraperitoneal injection of water soluble part of ethanol extract of zhu ling at the dosage of 2g (crude drug)/kg daily for consecutive 10 days had an inhibitory rate of 62% on Sarcoma180 in mice, and 37~54% on liver cancer of mice. But it had no effects on mice leukemia L615..

1. Combined effects of chuling (Polyporus umbellatus) extract and mitomycin C on experimental liver cancer.

Chuling (Polyporus umbellatus), one of the commonly used Chinese medical herbs, was combined with mitomycin C and then studied against intrahepatic implantation of sarcoma 180 tumor cells in mice. Oral administration of chuling extract, intraperitoneal injection of mitomycin C and the combination of both increased the life span of tumor-bearing mice 71.6%, 70.1% and 119.9%, respectively. The same treatments were found to be cytotoxic to Sarcoma-180-induced liver tumor cells. The synthetic rates of DNA, RNA and protein were all inhibited measurably by the combined treatment. Histopathological studies showed that lymphocytes infiltrated and surrounded the cancer cells, and there was some fibrosis found in normal cells and cancer cells. These results indicate the potential use of chuling as an anticancer agent.

--You JS, Hau DM, Chen KT, Huang HF. Am J Chin Med. 1994;22(1):19-28.

2. Studies on constituents of fruit body onload="highlight();" of Polyporus umbellatus and their cytotoxic activity.

From the crude drug Chorei, the fruit body onload="highlight();" of Polyporus umbellatus, seven new components named polyporusterone A, B, C, D, E, F and G, were isolated and their structures were determined on the basis of the spectral data. These compounds showed cytotoxic action on leukemia 1210 cell proliferation.

--Ohsawa T, Yukawa M, Takao C, Murayama M, Bando H. Chem Pharm Bull (Tokyo). 1992 Jan;40(1):143-7.

Effects over immune system

zhu ling was a kind of nonspecific immune stimulant. It also had antibacterial effect.

Liver protecting effect

Polysaccharide of zhu ling could fix injured liver and reduce the pathogenic injury of liver tissues.

 Clinical Studies Back to Top

zhu ling extract 757 was used to treat lung cancer and oesophagus cancer and it's believed preliminarily that it had anti-tumor effects and could improve immune function.

Chronic viral hepatitis

Zhu Ling Polysaccharide Injection, 40mg, im for consecutive 20 days with an interval of 10 days, 3 months as a course of treatment. It could significantly improve symptoms, lower GPT and fix injured liver tissues.


Modified Wu Ling San was made into tablets to treat 20 cases of infantile edema due to nephritis. In 17 cases, symptoms completely disappeared, 2 relievd and 1 ineffective.

Chronic congestive heart failure

25 cases of chronic congestive heart failure was treated with supplemented Wu Ling San. Results: 12 were markedly effective, 11 improved, 1 ineffective and 1 death.


zhu ling, fu ling, ze xie, e jiao, hua shi, 9g each, water decoction.

Ascites due to hepatocirrhosis

Modified Wu Ling San combininb Wu Pi Yin had effects on ascites due to hepatocirrhosis, edema and infections of urinary system.

 References Back to Top

Except those noted, all references come from Weng Weiliang, et al., Clinical Chinese materia medica, Henan Science & Technology Press, 1998